Acarbose, an α-Glucosidase Inhibitor, Attenuates Postprandial Hypotension in Autonomic Failure
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منابع مشابه
Acarbose, an -Glucosidase Inhibitor, Attenuates Postprandial Hypotension in Autonomic Failure
Postprandial hypotension is an important clinical condition that predisposes to syncope, falls, angina, and cerebrovascular events. The magnitude of the fall in blood pressure after meals depends on enteric glucose availability. We hypothesized that acarbose, an -glucosidase inhibitor that decreases glucose absorption in the small intestine, would attenuate postprandial hypotension. Acarbose or...
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Acarbose and Postprandial Hypotension To the Editor: We read with interest the article by Shibao et al,1 who reported that acute administration of acarbose had a substantial, beneficial effect on the hypotensive response to a high-carbohydrate meal in patients with autonomic failure. It was suggested that this effect is mediated, at least in part, by a reduction in the insulinemic response to a...
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The inhibitory activity on intestinal α-glucosidase by cyanidin-3-rutinoside was examined in vitro and in vivo. The IC(50) values of cyanidin-3-rutinoside against intestinal maltase, and sucrase were 2,323 ± 14.8 and 250.2 ± 8.1 µM, respectively. The kinetic analysis revealed that intestinal sucrase was inhibited by cyanidin-3-rutinoside in a mixed-type manner. The synergistic inhibition also f...
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ژورنال
عنوان ژورنال: Hypertension
سال: 2007
ISSN: 0194-911X,1524-4563
DOI: 10.1161/hypertensionaha.107.091355